一 、 个人简介
李振华，博士，副教授，硕士生导师。2005 年本科毕业于河北大学生命科学学院生物工程专业，2015 年于中科院长春应用化学研究所取得理学博士学位。
随后，加入河北大学化学与环境科学学院。申请人长期致力于多功能生物纳米材料的合成及其在生物医药领域的应用。申请人针对传统的药物小分子选择性低、毒副作用大、溶解性差等问题，通过纳米载体负载及靶向修饰等手段，开发出了一系列新型纳米载药体系用于肿瘤的治疗。同时，考虑到传统化疗药物高的毒副作用、易使肿瘤细胞对药物产生耐药性以及难以对转移癌产生理想的效果等问题，申请者在肿瘤的免疫治疗方面做了多篇具有影响力的工作。此外，针对耐药菌的发展及抗生素对其难以发挥作用的问题，申请者在抗耐药菌材料方面也做了一系列有意义的工作。相关工作发表在欧美著名的学术期刊上。迄今为止，已经发表 40 余篇高水平 SCI 学术论文，其中以第一或者通讯作者发表在 Materials Today (IF=21.695)，Advanced FunctionalMaterials (IF=11.805), Biomaterials (IF=8.402), Chemical Communications(IF=6.834) 等国际顶尖期刊 10 余篇，所有文章累计已被引用 1200 余次。作为课题负责人，正在主持包括国家自然科学基金在内的多项基金。
二 、 教育经历：
2009/9 - 2015/1，中国科学院长春应用化学研究所，无机化学专业，博士，导师：
任劲松（国家杰青、中科院“百人”）
2005/9 - 2009/6，河北大学，生物工程专业，学士
工作经历：
2015/1 - 至今，河北大学，化学与环境科学学院，副教授
三 、 主持或参加科研项目及人才计划项目情况：
1、国家自然科学基金青年科学基金项目，21601046，靶向肿瘤乏氧区的智能载
药体系的构建及其抗肿瘤作用研究、2017 年 01 月至 2019 年 12 月、19 万、在研、
主持人。
2、河北省自然科学基金项目，B2015201097、多功能上转换纳米药物载体连接
的间充质干细胞：新型“细胞补丁”用于肿瘤趋向的治疗、2015 年 01 月至 2017
年 12 月、4 万、在研、主持人。
3、国家自然科学基金青年科学基金项目，31500812、双重靶向肿瘤干细胞的多
功能磁性二氧化硅纳米体系的构建及其热化疗干预机制研究、2016 年 01 月至
2018 年 12 月、19 万、在研、第二参与人。
4、国家自然科学基金青年科学基金项目，21301169、多功能稀土上转换荧光复
合材料在癌症的靶向成像双重治疗中的应用、2014 年 1 月至 2016 年 12 月、25
万、已结题、第二参与人。
四 、科研奖励
基于 pH 响应及抗原和 CpG 核酸共载的纳米疫苗运载体系的构建、保定市科技
进步奖、一等奖、第一完成人
五 、研究成果
(1) Kai Dong # , Zhenhua Li # , Hanjun Sun, Enguo Ju, Jinsong Ren* and Xiaogang
Qu*. Pathogen-mimicking Nanocomplexes: Self-stimulating Oxidative Stress in
Tumor Microenvironment for Chemo-immunotherapy. Materials Today, DOI:
10.1016/j.mattod.2017.06.003 (In press). ( # 共同第一作者)
(2) Fei Duan, Xiaochen Feng, Xinjian Yang, Wentong Sun, Yi Jin, Huifang Liu, Kun
Ge, Xing-Jie Liang, Zhenhua Li* and Jinchao Zhang*. A Simple and Powerful
Co-Delivery System Based on pH-Responsive Metal-Organic Frameworks for
Enhanced Cancer Immunotherapy. Biomaterials, 2017, 122, 23-33.
(3) Huihui Ren, # Shizhu Chen, # Yanan Jin, Cuimiao Zhang, Xinjian Yang, Kun Ge,
Xing-Jie Liang, Zhenhua Li * and Jinchao Zhang*. A Traceable and
Bone-targeted Nanoassembly Based on Defect-related Luminescent Mesoporous
Silica for Enhanced Osteogenic Differentiation. Journal of Materials Chemistry
B, 2017, 5, 1585-1593..
(4) Zhenhua Li, Zhen Liu, Zhaowei Chen, Enguo Ju, Wei Li, Jinsong Ren* and
Xiaogang Qu*. Bioorthogonal chemistry for selective recognition, separation and
killing bacteria over mammalian cells. Chemical Communications 2016, 52,
3482-3485.
(5) Zhenhua Li, Kai Dong, Yan Zhang, Enguo Ju, Zhaowei Chen, Jinsong Ren*
and Xiaogang Qu*. Biomimetic nanoassembly for targeted antigen delivery and
enhanced Th1-type immune response. Chemical Communications 2015, 51,
15975-15978.
(6) Zhenhua Li, Kai Dong, Sa Huang, Enguo Ju, Zhen Liu, Meili Yin, Jinsong
Ren* and Xiaogang Qu*. A smart nanoassembly for multistage targeted drug
delivery and magnetic resonance imaging. Advanced Functional Materials 2014,
24, 3612-3620.
(7) Xinjian Yang # , Zhenhua Li
# , Enguo Ju, Jinsong Ren* and Xiaogang Qu*.
Luminescent Rare-Earth Complex Functionalized Reduced Graphene Oxide for
Tracking, and Photothermal Killing Drug-Resistant Bacteria. Chemistry-A
European Journal 2014, 20, 394-398. ( # 共同第一作者)
(8) Zhenhua Li, Yu Tao, Sa Huang, Nan Gao, Jinsong Ren* and Xiaogang Qu*.
Lanthanide-based hollow mesoporous nanoparticles: a novel multifunctional
platform for simultaneous gene delivery and cell imaging. Chemical
Communications 2013, 49 (64), 7129-7131.
(9) Zhenhua Li, Zhen Liu, Meili Yin, Xinjian Yang, Jinsong Ren* and Xiaogang
Qu*. Combination Delivery of Antigens and CpG by Lanthanides-based
core-shell nanoparticles for enhanced immune response and dual-mode imaging.
Advanced Healthcare Materials 2013, 2, 1309-1313.
(10) Zhenhua Li, Zhen Liu, Meili Yin, Xinjian Yang, Qinghai Yuan, Jinsong Ren*
and Xiaogang Qu*. Aptamer-capped multifunctional mesoporous strontium
hydroxyapatite nanovehicle for cancer-cell-responsive drug delivery and imaging.
Biomacromolecules, 2012, 13 (12), 4257-4263.
(11) Zhaowei Chen, Zhenhua Li, Youhui Lin, Meili Yin, Jinsong Ren* and
Xiaogang Qu*. Biomineralization inspired surface engineering of nanocarriers
for pH-responsive, targeted drug delivery. Biomaterials 2013, 34, 1364.
(12) Zhaowei Chen, Zhenhua Li, Youhui Lin, Meili Yin, Jinsong Ren* and
Xiaogang Qu*. Bioresponsive hyaluronic Acid-capped mesoporous silica
nanoparticles for targeted drug delivery. Chemistry-A European Journal 2013,
19, 1778.
(13) Zhaowei Chen, Zhenhua Li, Jiasi Wang, Enguo Ju, Li Zhou, Jinsong Ren* and
Xiaogang Qu*. A Multi-synergistic Platform for Sequential
Irradiation-Activated High-Performance Apoptotic Cancer Therapy. Advanced
Functional Materials 2014, 24, 522.
(14) Enguo Ju, Zhenhua Li, Meng Li, Kai Dong, Jinsong Ren* and Xiaogang Qu*.
Functional polypyrrole-silica composites as photothermal agents for targeted
killing of bacteria. Chemical Communications 2013, 49, 9048.
(15) Youhui Lin, Zhenhua Li, Zhaowei Chen, Jinsong Ren* and Xiaogang Qu*.
Mesoporous silica-encapsulated gold nanoparticles as artificial enzymes for
self-activated cascade catalysis. Biomaterials 2013, 34, 2600.
(16) Li Zhou, Zhenhua Li, Enguo Ju, Zhen Liu, Jinsong Ren* and Xiaogang Qu*.
Aptamer-Directed Synthesis of Multifunctional Lanthanide-Doped Porous
Nanoprobes for Targeted Imaging and Drug Delivery. Small 2013, 9, 4262.
(17) Li Zhou, Zhenhua Li, Zhen Liu, Jinsong Ren* and Xiaogang Qu.
Luminescent Carbon Dot-gated Nanovehicles for pH-triggered Intracellular
Controlled Release and Imaging. Langmuir 2013, 29, 6396.
(18) Li Zhou, Zhenhua Li, Zhen Liu, Meili Yin, Jinsong Ren* and Xiaogang Qu*.
One-step Nucleotide-programmed Growth of Porous Upconversion
Nanoparticles: Application to Cell Labeling and Drug Delivery. Nanoscale
2014, 6, 1445.
(19) Yu Tao, Zhenhua Li, Enguo Ju, Jinsong Ren* and Xiaogang Qu*.
Polycations-functionalized water-soluble gold nanoclusters: a potential platform
for simultaneous enhanced gene delivery and cell imaging. Nanoscale 2013, 5,
6154.
(20) Yu Tao, Zhenhua Li, Enguo Ju, Jinsong Ren* and Xiaogang Qu*. One-step
DNA-programmed growth of CpG conjugated silver nanoclusters: a potential
platform for simultaneous enhanced immune response and cell imaging.
Chemical Communications 2013, 49, 6918.
(21) Zhen Liu, Zhenhua Li, Jianhua Liu, Song Gu, Qinghai Yuan, Jinsong Ren* and
Xiaogang Qu*. Long-circulating Er 3+ -doped Yb 2 O 3 up-conversion nanoparticle
as an in vivo X-Ray CT imaging contrast agent. Biomaterials 2012, 33, 6748.
(22) Meili Yin, Zhenhua Li, Zhen Liu, Jinsong Ren,* Xinjian Yang, and Xiaogang
Qu.* Photosensitizer-incorporated G-quadruplex DNA-functionalized
magnetofluorescent nanoparticles for targeted magnetic resonance/fluorescence
multimodal imaging and subsequent photodynamic therapy of cancer. Chemical
Communications 2012, 48, 6556.
(23) Meili Yin, Zhenhua Li, Zhen Liu, Xinjian Yang, Jinsong Ren*. Magnetic
self-assembled zeolite clusters for sensitive detection and rapid removal of
mercury(II). ACS Applied Materials & Interfaces 2012, 4, 431.
(24) Meili Yin, Zhenhua Li, Enguo Ju, Zhenzhen Wang, Kai Dong, Jinsong Ren*
and Xiaogang Qu*. Multifunctional upconverting nanoparticles for
near-infrared triggered and synergistic antibacterial resistance therapy.
Chemical Communications 2014, 50, 10488-10490.
(25) Meili Yin, Zhenhua Li, Li Zhou, Kai Dong, Jinsong Ren* and Xiaogang Qu*.
A multifunctional upconverting nanoparticle incorporated polycationic hydrogel
for near-infrared triggered and synergistic treatment of drug-resistant bacteria.
Nanotechnology 2016, 27.
(26) Enguo Ju, Zhenhua Li, Zhen Liu, Jinsong Ren* and Xiaogang Qu*.
Near-Infrared Light-Triggered Drug-Delivery Vehicle for
Mitochondria-Targeted Chemo-Photothermal Therapy. ACS Applied Materials
& Interfaces 2014, 6, 4364.
(27) Enguo Ju, Zhenhua Li, Meng Li, Kai Dong, Jinsong Ren* and Xiaogang Qu*.
Functional polypyrrole-silica composites as photothermal agents for targeted
killing of bacteria. Chemical Communications 2013, 49, 9048-9050.
(28) Xinjian Yang, Zhenhua Li, Meng Li, Jinsong Ren* and Xiaogang Qu*.
Fluorescent Protein Capped Mesoporous Nanoparticles for Intracellular Drug
Delivery and Imaging. Chemistry-A European Journal 2013, 19,
15378-15383.
(29) Kai Dong, Zhen Liu, Zhenhua Li, Jinsong Ren* and Xiaogang Qu*.
Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven
Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo.
Advanced Materials 2013, 25, 4452-4458.
(30) Zhen Liu, Meng Li, Zhenhua Li, Fang Pu, Jinsong Ren* and Xiaogang Qu.
Easy access to selective binding and recyclable separation of histidine-tagged
proteins using Ni 2+ -decorated superparamagnetic nanoparticles. Nano Research
2012, 5, 450-459.
(31) Yu Tao, Enguo Ju, Zhenhua Li, Jinsong Ren* and Xiaogang Qu*. Engineered
CpG-Antigen Conjugates Protected Gold Nanoclusters as Smart Self-Vaccines
for Enhanced Immune Response and Cell Imaging. Advanced Functional
Materials 2014, 24, 1004-1010.
(32) Zhaowei Chen, Zhen Liu, Zhenhua Li, Enguo Ju, Nan Gao, Li Zhou, Jinsong
Ren* and Xiaogang Qu*. Upconversion nanoprobes for efficiently in vitro
imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis.
Biomaterials 2015, 39, 15-22.
(33) Xinjian Yang, Zhen Liu, Zhenhua Li, Fang Pu, Jinsong Ren* and Xiaogang
Qu*. Near-Infrared-Controlled, Targeted Hydrophobic Drug-Delivery System
for Synergistic Cancer Therapy. Chemistry-A European Journal 2013, 19,
10388-10394.
(34) Meili Yin, Li Wu, Zhenhua Li, Jinsong Ren* and Xiaogang Qu. Facile in situ
fabrication of graphene-upconversion hybrid materials with amplified
electrogenerated chemiluminescence. Nanoscale 2012, 4, 400-404.
(35) Meili Yin, Enguo Ju, Zhaowei Chen, Zhenhua Li, Jinsong Ren* and Xiaogang
Qu*. Upconverting Nanoparticles with a Mesoporous TiO2 Shell for
Near-Infrared-Triggered Drug Delivery and Synergistic Targeted Cancer
Therapy. Chemistry-A European Journal 2014, 20, 14012-14017.
(36) Wei Li, Zhaowei Chen, Li Zhou, Zhenhua Li, Jinsong Ren* and Xiaogang
Qu*. Noninvasive and Reversible Cell Adhesion and Detachment via
Single-Wavelength Near-Infrared Laser Mediated Photoisomerization. Journal
of the American Chemical Society 2015, 137, 8199-8205.
(37) Zhaowei Chen, Li Zhou, Wei Bing, Zhijun Zhang, Zhenhua Li, Jinsong Ren*
and Xiaogang Qu*. Light Controlled Reversible Inversion of
Nanophosphor-Stabilized Pickering Emulsions for Biphasic Enantioselective
Biocatalysis. Journal of the American Chemical Society 2014, 136,
7498-7504.
(38) Kun Ge, Cuimiao Zhang, Wentong Sun, Huifang Liu, Yi Jin, Zhenhua Li,
Xing-Jie Liang, Guang Jia* and Jinchao Zhang*. Up-Conversion Y 2 O 3 :Yb 3+ ,
Er 3+ Hollow Spherical Drug Carrier with Improved Degradability for Cancer
Treatment. ACS Applied Materials & Interfaces 2016, 8, 25078-25086.
(39) Xiaohong Hao, Xixue Hu, Cuimiao Zhang, Shizhu Chen, Zhenhua Li, Xinjian
Yang, Huifang Liu, Guang Jia,* Dandan Liu, Kun Ge, Xing-Jie Liang,* and
Jinchao Zhang.* Hybrid Mesoporous Silica-Based Drug Carrier Nanostructures
with Improved Degradability by Hydroxyapatite. ACS Nano 2015, 9,
9614-9625.
(40) Wentong Sun, Yu Han, Zhenhua Li, Kun Ge,* and Jinchao Zhang.*
Bone-Targeted Mesoporous Silica Nanocarrier Anchored by Zoledronate for
Cancer Bone Metastasis. Langmuir 2016, 32, 9237-9244.